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Sexual health · TREATMENT GUIDE

Alprostadil cream guide

How to apply prescribed alprostadil cream for erectile dysfunction, with dose, application, and partner precautions.

2 min read · Reviewed by Dr. Alejandro Infante
TREATMENT GUIDE · Sexual health

Alprostadil cream guide

How to apply prescribed alprostadil cream for erectile dysfunction, with dose, application, and partner precautions.

READ TIME
2 min read
PATHWAY
Topical (Alprostadil)

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Medicines and interactions to reviewAnticoagulants and other erectile-dysfunction treatments need review before use

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On this page
01

How to use

  1. Apply 5-30 minutes before activity

    Hold the applicator tip as close as possible to the opening at the tip of the penis and apply all the cream. Do not insert the applicator into the opening. The strength is alprostadil 300 mcg.

  2. Partner precautions

    If the partner is pregnant or trying to conceive, use a condom. Wash hands after application.

Monitoring

Medicines and interactions to review. Anticoagulants and other erectile-dysfunction treatments need review before use Use a condom if the partner is pregnant or could become pregnant

02

Dose schedule

  1. Short acting, per occasion

    Use one single-dose container per occasion, only once in a 24-hour period and no more than 2-3 times per week.

  2. Review response

    If not satisfactory after several proper attempts, discuss with the prescriber.

03

Side effects

Local effects

Penile or urethral burning, stinging, redness, or minor bleeding. Usually mild and brief.

Partner effects

Partner may experience vaginal burning or itching. Headache or dizziness possible. Priapism rare.

04

Do not use if

  • You are allergic to alprostadil or any ingredient in the applicator
  • You have a condition that raises the risk of priapism or a penile condition that has not been reviewed
  • A clinician has advised that sexual activity is unsafe because of a heart condition

If any item may apply, do not use the medicine until a clinician has reviewed it.

05

When to contact your doctor

  • An erection lasting 4 hours or longer: seek urgent care
  • Severe penile pain, bleeding, rash, or persistent swelling
  • The prescribed dose does not provide a satisfactory response after several attempts
06

Storage

Store in a refrigerator at 2-8°C and do not freeze. An unopened sachet may be kept below 25°C for up to 3 days before use; discard it if unused after that period. Keep it in the original sachet to protect it from light.

07

What to expect

Alprostadil cream works locally and requires sexual stimulation. Effect within 5-30 minutes lasting about 1-2 hours.

08

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Common questions

Alprostadil cream guide3 questions
Who writes the guides?
Each guide is written and reviewed by an EU-licensed doctor and based on the official product information (SmPC).
No. They support your treatment, and your doctor's instructions always come first.
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All content on this page has been medically reviewed by: Dr. Alejandro Infante, General medicine, on 26 August 2026. Registration: 080869277 View profile

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