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Sexual health · TREATMENT GUIDE

Avanafil guide

On-demand use of prescribed avanafil for erectile dysfunction, with timing and interaction safety advice.

2 min read · Reviewed by Dr. Alejandro Infante
TREATMENT GUIDE · Sexual health

Avanafil guide

On-demand use of prescribed avanafil for erectile dysfunction, with timing and interaction safety advice.

READ TIME
2 min read
PATHWAY
Avanafil 50/100/200mg

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Medicines and interactions to reviewYou use nitrates, nitric oxide donors such as poppers, or riociguat

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On this page
01

How to use

  1. Take about 15-30 minutes before activity

    Swallow the tablet whole with water. Use only the prescribed 50 mg, 100 mg, or 200 mg strength. Avanafil works only with sexual stimulation.

  2. Food and dose timing

    It can be taken with or without food, although food may delay the onset. Do not exceed one dose in 24 hours. Avoid grapefruit juice.

  3. Never combine with nitrates or riociguat

    Do not take avanafil with nitrate medicines, nitric oxide donors such as poppers, or riociguat. The combination can cause a dangerous fall in blood pressure.

Monitoring

Medicines and interactions to review. You use nitrates, nitric oxide donors such as poppers, or riociguat Alpha-blockers, strong CYP3A4 inhibitors, other erectile-dysfunction medicines, and grapefruit need review

02

Dose schedule

  1. As needed, not more than once daily

    Take only when sexual activity is planned. Do not combine with other PDE5 inhibitors.

  2. Review effectiveness

    If the prescribed dose is not effective after several attempts, discuss with the prescriber.

03

Side effects

Common vascular effects

Headache, facial flushing, nasal congestion, back pain, dizziness. Usually mild and resolve.

Prolonged erection

Priapism (over 4 hours) is rare and needs urgent care. Sudden vision or hearing loss is very rare.

04

Do not use if

  • You use nitrates, nitric oxide donors such as poppers, or riociguat
  • A clinician has advised that sexual activity is unsafe because of a heart condition
  • You have a serious liver condition, very low blood pressure, or a recent stroke or heart attack that has not been reviewed

If any item may apply, do not use the medicine until a clinician has reviewed it.

05

When to contact your doctor

  • An erection that does not go away, sudden loss of vision or hearing, chest pain, collapse, or a severe allergic reaction: seek urgent care
  • Marked dizziness, fainting, palpitations, or a headache that is severe or persistent
  • The prescribed dose is not suitable or does not provide a satisfactory response after several correctly timed attempts
06

Storage

Keep in the original package, away from moisture and direct heat, and out of children's reach. Follow the temperature limit on your pack and do not use it after the expiry date.

07

What to expect

Erectile dysfunction treatments work in most cases but not every attempt. Requires sexual arousal. Several tries may be needed.

08

Sources

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FAQS

Common questions

Avanafil guide3 questions
Who writes the guides?
Each guide is written and reviewed by an EU-licensed doctor and based on the official product information (SmPC).
No. They support your treatment, and your doctor's instructions always come first.
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All content on this page has been medically reviewed by: Dr. Alejandro Infante, General medicine, on 26 August 2026. Registration: 080869277 View profile

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