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Smoking cessation · TREATMENT GUIDE

Varenicline guide

How to take varenicline to help stop smoking, with the dosing schedule, quit date timing, and support for side effects.

2 min read · Reviewed by Dr. Alejandro Infante
TREATMENT GUIDE · Smoking cessation

Varenicline guide

How to take varenicline to help stop smoking, with the dosing schedule, quit date timing, and support for side effects.

READ TIME
2 min read
PATHWAY
Smoking cessation

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On this page
01

How to use

  1. Start 1-2 weeks before your quit date

    Take 0.5 mg once daily for 3 days, then 0.5 mg twice daily for 4 days, then 1 mg twice daily. Set a quit date between days 8 and 14.

  2. Take with a full glass of water after food

    Taking the tablets with water after food can help reduce nausea.

02

Dose schedule

  1. Week 1: dose escalation

    0.5 mg once daily (days 1-3), then 0.5 mg twice daily (days 4-7). The planned quit date is usually 1-2 weeks after starting.

  2. Week 2 onwards: maintenance

    1 mg twice daily for the remainder of the 12-week course. Complete the course even if you stop smoking early.

03

Side effects

Nausea and gastrointestinal effects

Nausea is the most common side effect. Taking with food and water helps. Constipation, gas, and vomiting can also occur.

Mood and sleep changes

Unusual dreams, insomnia, headache, mood changes, and dizziness can occur. Report severe low mood or suicidal thoughts.

04

When to contact your doctor

  • Severe low mood, agitation, suicidal thoughts, or unusual behaviour: stop and seek urgent help
  • Severe or persistent nausea, skin reactions, or swelling of the face or throat
05

Storage

Keep in the original package, away from moisture and direct heat, and out of children's reach. Follow the temperature limit on your pack and do not use it after the expiry date.

06

What to expect

Varenicline helps reduce cravings and withdrawal symptoms. It works best when you set a quit date and follow the dose escalation. Combining with behavioural support improves success rates.

07

Sources

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FAQS

Common questions

Varenicline guide3 questions
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Each guide is written and reviewed by an EU-licensed doctor and based on the official product information (SmPC).
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All content on this page has been medically reviewed by: Dr. Alejandro Infante, General medicine, on 26 August 2026. Registration: 080869277 View profile

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