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Chlamydia · TREATMENT GUIDE

Doxycycline for chlamydia guide

How to take the 7-day course of doxycycline for chlamydia and prevent reinfection.

2 min read · Reviewed by Dr. Alejandro Infante
TREATMENT GUIDE · Chlamydia

Doxycycline for chlamydia guide

How to take the 7-day course of doxycycline for chlamydia and prevent reinfection.

READ TIME
2 min read
PATHWAY
Doxycycline

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On this page
01

How to use

  1. Take one capsule twice daily for 7 days

    Swallow 100 mg whole with plenty of water while sitting or standing. Take it twice daily for the prescribed 7-day course and avoid taking it just before lying down.

  2. Check interacting medicines and supplements

    Antacids and products containing iron, zinc, or bismuth can reduce absorption. Ask a pharmacist how to separate them from doxycycline. Food or milk does not materially reduce doxycycline absorption.

Monitoring

Medicines and interactions to review. Antacids, iron, zinc, bismuth, enzyme-inducing medicines, anticoagulants, and oral retinoids need review

02

Treatment pathway

See the full decision pathway

Treatment and follow-up

    • Confirm uncomplicated chlamydia

      Testing, infection site, symptoms, pregnancy, and possible coinfections determine whether this pathway is safe.

    • Use the selected regimen

      Doxycycline 100 mg every 12 hours for 7 days is first line. Azithromycin 1 g once is the clinician-selected alternative when doxycycline is unsuitable.

    • Prevent reinfection

      Complete treatment, follow the no-sex interval, ensure partners are treated, and repeat testing at about 3 months.

03

Dose schedule

  1. Twice daily for 7 days

    Complete all 7 days. Missing doses reduces the chance of clearing the infection.

  2. Sexual abstinence and partner notification

    Avoid sexual contact until you and partner(s) complete treatment. Partners need treatment even without symptoms.

  3. If you miss a dose

    Take it when remembered unless the next dose is nearly due. Do not take two doses together; complete all 7 days.

04

Side effects

Sun sensitivity and gastrointestinal effects

Increased sun sensitivity: use high-factor sunscreen. Nausea, diarrhoea, indigestion possible.

Oesophageal and yeast effects

Stay upright after taking to avoid oesophageal irritation. Vaginal yeast infection possible.

05

Do not use if

  • You are allergic to doxycycline or another tetracycline
  • You are pregnant or pregnancy has not been excluded
  • You use isotretinoin or another oral retinoid

If any item may apply, do not use the medicine until a clinician has reviewed it.

06

When to contact your doctor

  • Severe skin reaction, facial swelling, breathing difficulty, or widespread rash
  • Severe headache, vision changes, or persistent vomiting
  • Chlamydia symptoms persist after completing the full course
07

Storage

Keep in the original package, away from moisture and direct heat, and out of children's reach. Follow the temperature limit on your pack and do not use it after the expiry date.

08

What to expect

Complete the 7-day course without missing doses. For uncomplicated infection in a non-pregnant person, a routine test of cure is not advised unless adherence is uncertain, symptoms persist, or reinfection is suspected. Retesting at about 3 months is recommended.

09

Sources

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Common questions

Doxycycline for chlamydia guide3 questions
Who writes the guides?
Each guide is written and reviewed by an EU-licensed doctor and based on the official product information (SmPC).
No. They support your treatment, and your doctor's instructions always come first.
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All content on this page has been medically reviewed by: Dr. Alejandro Infante, General medicine, on 26 August 2026. Registration: 080869277 View profile

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